(Q39606430)

13 September 2017

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy (English)

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13 September 2017

2

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13 September 2017

Florian Mulks

4

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David J Wright

object named as

David J Wright

3

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James M. McDonnell

object named as

James M McDonnell

7

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author name string

Christiane Riedinger

1

1 reference

PubMed ID

21244642

13 September 2017

Ian R Hardcastle

5

1 reference

PubMed ID

21244642

13 September 2017

Jane A Endicott

6

1 reference

13 September 2017

1 March 2011

1 reference

Chemical Biology and Drug Design

13 September 2017

1 reference

13 September 2017

77

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13 September 2017

5

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13 September 2017

301-308

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Principles of tumor suppression

13 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

p53 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

The MDM2 gene amplification database

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Inhibitors of MDM2 and MDMX: a structural perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01091.X

10.1111/J.1747-0285.2011.01091.X

21 January 2018

Identifiers

DOI

1 reference

13 September 2017

1 reference

PubMed ID

21244642