(Q39989774)

16 September 2017

title

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction (English)

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16 September 2017

Anna Czarna

2

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Lutz Weber

9

object named as

Lutz Weber

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16 September 2017

Ulli Rothweiler

1

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16 September 2017

Marcin Krajewski

3

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16 September 2017

Jolanta Ciombor

4

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16 September 2017

Cédric Kalinski

5

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16 September 2017

Vladimir Khazak

6

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16 September 2017

Günther Ross

7

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16 September 2017

Natalia Skobeleva

8

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16 September 2017

Tad A Holak

10

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16 September 2017

publication date

1 July 2008

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16 September 2017

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16 September 2017

volume

3

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16 September 2017

issue

7

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16 September 2017

page(s)

1118-1128

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Mapping of the p53 and mdm-2 interaction domains

16 September 2017

cites work

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https://api.crossref.org/works/10.1002%2FCMDC.200800025

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Cancer. p53, guardian of the genome

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Surfing the p53 network

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The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

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7 January 2021

The p53-Mdm2 module and the ubiquitin system.

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7 January 2021

The MDM2 gene amplification database

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Functions of the MDM2 oncoprotein

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p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

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A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.

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Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

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7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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7 January 2021

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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7 January 2021

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

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7 January 2021

Patented small molecule inhibitors of p53-MDM2 interaction

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7 January 2021

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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7 January 2021

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

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7 January 2021

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

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7 January 2021

Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy

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7 January 2021

An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments

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7 January 2021

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7 January 2021

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation

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7 January 2021

Condensation of imines with homophthalic anhydrides. A convergent synthesis of cis- and trans-13-methyltetrahydroprotoberberines

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7 January 2021

Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids

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7 January 2021

Synthesis of trans/cis 4-substituted 3-furyl-2-phenethyltetrahydroisoquinolin-1-ones: conformation of the trans-4-(pyrrolidinylcarbonyl) derivative

1 reference

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7 January 2021

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

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7 January 2021

Inactivation of the p53 pathway in retinoblastoma.

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7 January 2021

1) Ueber α-Alkylcinchoninsäuren und α-Alkylchinoline

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200800025

1 reference

16 September 2017

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