(Q39627618)

13 September 2017

Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis (English)

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13 September 2017

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Nyree Crawford

1

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13 September 2017

Alex D Chacko

2

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13 September 2017

Kienan I Savage

3

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13 September 2017

Francis McCoy

4

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13 September 2017

Kelly Redmond

5

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13 September 2017

Daniel B Longley

6

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13 September 2017

Dean A Fennell

7

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13 September 2017

1 March 2011

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13 September 2017

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13 September 2017

16

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13 September 2017

3

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13 September 2017

311-320

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https://scigraph.springernature.com/pub.10.1007/s10495-010-0561-1

13 September 2017

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

21 January 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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BID regulation by p53 contributes to chemosensitivity

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Proapoptotic BID is an ATM effector in the DNA-damage response

21 January 2018

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Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

21 January 2018

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AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

21 January 2018

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Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

21 January 2018

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Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

21 January 2018

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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

21 January 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

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BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

21 January 2018

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A role for mitochondrial Bak in apoptotic response to anticancer drugs

21 January 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance

21 January 2018

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Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma

21 January 2018

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BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma

21 January 2018

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The landscape of somatic copy-number alteration across human cancers

21 January 2018

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Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

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Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

21 January 2018

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A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0561-1

10.1007/S10495-010-0561-1

21 January 2018

Identifiers

DOI

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13 September 2017

1 reference