(Q39668365)

13 September 2017

Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events (English)

1 reference

13 September 2017

Christopher L Shaffer

1

1 reference

13 September 2017

Renato J Scialis

2

1 reference

13 September 2017

Haojing Rong

3

1 reference

13 September 2017

R Scott Obach

4

1 reference

13 September 2017

17 January 2012

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Biopharmaceutics and Drug Disposition

13 September 2017

1 reference

13 September 2017

33

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13 September 2017

72-84

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13 September 2017

2

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Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

13 September 2017

1 reference

The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

21 January 2018

1 reference

Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders

21 January 2018

1 reference

Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma

21 January 2018

1 reference

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

21 January 2018

1 reference

The Simcyp population-based ADME simulator

21 January 2018

1 reference

Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

21 January 2018

1 reference

Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia

21 January 2018

1 reference

Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction

21 January 2018

1 reference

A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human.

21 January 2018

1 reference

Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects

21 January 2018

1 reference

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review

21 January 2018

1 reference

Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

21 January 2018

1 reference

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

21 January 2018

1 reference

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

21 January 2018

1 reference

In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A.

21 January 2018

1 reference

Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.

21 January 2018

1 reference

Bioavailability considerations in evaluating drug-drug interactions using the population pharmacokinetic approach.

21 January 2018

1 reference

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

21 January 2018

1 reference

Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

21 January 2018

1 reference

Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator

21 January 2018

1 reference

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BDD.1768

1 reference

release_h4dkj3u7lfgqtfxslulrlgawhi

13 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/h4dkj3u7lfgqtfxslulrlgawhi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference