(Q43137258)

English

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

scientific article published in April 2010

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

drug interaction

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2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Marylore Chenel

4

object named as

Marylore Chenel

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Nathalie Perdaems

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Cedric Vinson

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Sarah Whalley

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Fanny Cazade

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

François Bouzom

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

publication date

1 April 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

49

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

239-258

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20214408%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

https://scigraph.springernature.com/pub.10.2165/11318130-000000000-00000

0 references

Physiologically based pharmacokinetic analyses of simple mixtures

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Commentary: a physiological approach to hepatic drug clearance

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Physiological parameter values for physiologically based pharmacokinetic models

1 reference

https://api.crossref.org/works/10.2165%2F11318130-000000000-00000

21 January 2018

Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative prediction of metabolic inhibition of midazolam by erythromycin, diltiazem, and verapamil in rats: implication of concentrative uptake of inhibitors into liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: the role of plasma protein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein increases from proximal to distal regions of human small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of midazolam and simvastatin as cytochrome P450 3A probes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole body pharmacokinetic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: structure-kinetics relationship assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in liver volume from birth to adulthood: a meta-analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Challenges and opportunities with modelling and simulation in drug discovery and drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketoconazole renders poor CYP3A phenotype status with midazolam as probe drug.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug interactions of new active substances: mibefradil example

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro methods to study intestinal drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of verapamil on serum digoxin concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report (Georgetown University, Washington, DC, May 29-30, 2002).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel strategy for physiologically based predictions of human pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20214408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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