(Q39680200)

English

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway

scientific article published on 14 July 2010

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway (English)

1 reference

Europe PubMed Central

13 September 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Dieter Häussinger

6

object named as

Dieter Häussinger

1 reference

Europe PubMed Central

13 September 2017

14

object named as

Paul Dent

1 reference

Europe PubMed Central

13 September 2017

9

object named as

Sarah Spiegel

1 reference

Europe PubMed Central

13 September 2017

author name string

Margaret A Park

1

1 reference

Europe PubMed Central

13 September 2017

Clint Mitchell

2

1 reference

Europe PubMed Central

13 September 2017

Guo Zhang

3

1 reference

Europe PubMed Central

13 September 2017

Adly Yacoub

4

1 reference

Europe PubMed Central

13 September 2017

Jeremy Allegood

5

1 reference

Europe PubMed Central

13 September 2017

Roland Reinehr

7

1 reference

Europe PubMed Central

13 September 2017

Andrew Larner

8

1 reference

Europe PubMed Central

13 September 2017

Paul B Fisher

10

1 reference

Europe PubMed Central

13 September 2017

Christina Voelkel-Johnson

11

1 reference

Europe PubMed Central

13 September 2017

Besim Ogretmen

12

1 reference

Europe PubMed Central

13 September 2017

Steven Grant

13

1 reference

Europe PubMed Central

13 September 2017

language of work or name

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publication date

14 July 2010

1 reference

Europe PubMed Central

13 September 2017

Cancer Research

1 reference

Europe PubMed Central

13 September 2017

70

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Europe PubMed Central

13 September 2017

15

1 reference

Europe PubMed Central

13 September 2017

6313-6324

1 reference

Europe PubMed Central

13 September 2017

Assessment of pancreatic cancer care in the United States based on formally developed quality indicators

1 reference

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BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing

1 reference

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Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms

1 reference

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Function of mitochondrial Stat3 in cellular respiration

1 reference

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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

1 reference

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Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

1 reference

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14 September 2017

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

1 reference

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14 September 2017

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918282

14 September 2017

Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation

1 reference

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Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling

1 reference

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From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now.

1 reference

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14 September 2017

Hyperosmotic activation of the CD95 system

1 reference

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B-Raf kinase inhibitors for cancer treatment

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The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress

1 reference

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Sorafenib: delivering a targeted drug to the right targets

1 reference

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Radiation-induced cell signaling: inside-out and outside-in

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Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits

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14 September 2017

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

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14 September 2017

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Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment

1 reference

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14 September 2017

Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma

1 reference

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Global cancer statistics, 2002

1 reference

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MAPK pathways in radiation responses

1 reference

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Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms.

1 reference

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14 September 2017

Histone deacetylases

1 reference

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Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

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Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

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Histone acetylation and chromatin remodeling

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

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Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1.

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Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation

1 reference

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1 reference

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Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

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The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

1 reference

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21 August 2018

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

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Kinase inhibitors and cytotoxic drug resistance.

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21 August 2018

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

1 reference

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Identifiers

10.1158/0008-5472.CAN-10-0999

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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