(Q39704674)

14 September 2017

title

A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer (English)

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14 September 2017

13

Li Jin

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14 September 2017

Shuyu Zhang

1

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14 September 2017

Juan Lu

2

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14 September 2017

Xueying Zhao

3

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14 September 2017

Wenting Wu

4

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14 September 2017

Huibo Wang

5

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14 September 2017

Jun Lu

6

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14 September 2017

Qihan Wu

7

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14 September 2017

Xin Chen

8

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14 September 2017

Weiwei Fan

9

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14 September 2017

Hongyan Chen

10

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14 September 2017

Feng Wang

11

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14 September 2017

Zhibin Hu

12

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14 September 2017

Qingyi Wei

14

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14 September 2017

Hongbing Shen

15

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14 September 2017

Wei Huang

16

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14 September 2017

Daru Lu

17

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14 September 2017

language of work or name

English

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publication date

12 May 2010

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14 September 2017

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14 September 2017

volume

31

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14 September 2017

issue

7

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14 September 2017

page(s)

1251-1258

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Global cancer statistics, 2002

14 September 2017

cites work

1 reference

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Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

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Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases

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Chk1 and Chk2 kinases in checkpoint control and cancer

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21 January 2018

The Chk2 protein kinase

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21 January 2018

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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Chk2 activates E2F-1 in response to DNA damage

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

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A p53-dependent checkpoint pathway prevents rereplication

21 January 2018

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

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A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

21 January 2018

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Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population

21 January 2018

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The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model.

21 January 2018

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CHEK2 is a multiorgan cancer susceptibility gene

21 January 2018

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Mutations in CHEK2 associated with prostate cancer risk

21 January 2018

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Bisulfite genomic sequencing: systematic investigation of critical experimental parameters

21 January 2018

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

21 January 2018

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Cigarette smoke is an endothelial stressor and leads to cell cycle arrest

21 January 2018

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Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells

21 January 2018

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Sp1 activates and inhibits transcription from separate elements in the proximal promoter of the human adenine nucleotide translocase 2 (ANT2) gene.

21 January 2018

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Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

21 January 2018

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CHEK2 variant I157T may be associated with increased breast cancer risk

21 January 2018

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Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

21 January 2018

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Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers

21 January 2018

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Methods for quantification of exposure to cigarette smoking and environmental tobacco smoke: focus on developmental toxicology

21 January 2018

1 reference

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CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ089

Chk2 down-regulation by promoter hypermethylation in human bulk gliomas

21 January 2018

1 reference

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Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features

21 January 2018

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Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells

21 January 2018

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Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGQ089

1 reference

14 September 2017

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