(Q40204866)

18 September 2017

title

Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells (English)

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18 September 2017

author name string

Pierre-Olivier Estève

series ordinal

1

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18 September 2017

Hang Gyeong Chin

series ordinal

2

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18 September 2017

Sriharsa Pradhan

series ordinal

3

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18 September 2017

language of work or name

English

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publication date

22 November 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

issue

4

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18 September 2017

page(s)

2615-2625

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

18 September 2017

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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

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The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

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The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancer

21 January 2018

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Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation

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GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

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Transcription from a TATA-less promoter requires a multisubunit TFIID complex

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CpG islands and genes

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Sp1 elements protect a CpG island from de novo methylation

21 January 2018

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Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

21 January 2018

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Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

21 January 2018

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

21 January 2018

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Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elements

21 January 2018

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Mammalian DNA (cytosine-5) methyltransferases and their expression

21 January 2018

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DNA methyltransferase Dnmt1 associates with histone deacetylase activity

21 January 2018

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Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

21 January 2018

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The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity

21 January 2018

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

21 January 2018

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Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

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Chromatin modifying activity of leukaemia associated fusion proteins

21 January 2018

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Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

21 January 2018

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

21 January 2018

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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

21 January 2018

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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21 January 2018

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21 January 2018

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Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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DNA damage-induced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1.

21 January 2018

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A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

21 January 2018

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Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

21 January 2018

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

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Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.

21 January 2018

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Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

21 January 2018

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Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.

21 January 2018

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Inhibition of melanoma tumor growth in vivo by survivin targeting

21 January 2018

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Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia.

21 January 2018

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Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M606203200

1 reference

18 September 2017

1 reference