(Q39732713)

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The DNA damage response to non-replicating adeno-associated virus: Centriole overduplication and mitotic catastrophe independent of the spindle checkpoint.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20199789%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

The DNA damage response to non-replicating adeno-associated virus: Centriole overduplication and mitotic catastrophe independent of the spindle checkpoint (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20199789%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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19 January 2020

Carin K Ingemarsdotter

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Carin Ingemarsdotter

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19 January 2020

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Peter Beard

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19 January 2020

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2 March 2010

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

271-286

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Europe PubMed Central

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19 January 2020

How adeno-associated virus Rep78 protein arrests cells completely in S phase

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Programs for cell death: apoptosis is only one way to go.

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Caffeine inhibits the checkpoint kinase ATM

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Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine

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DNA damage induces Chk1-dependent centrosome amplification.

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ATR Regulates Fragile Site Stability

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CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

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Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells.

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Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint

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Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

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Involvement of centrosome amplification in radiation-induced mitotic catastrophe

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Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents

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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

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Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype

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BubR1 is involved in regulation of DNA damage responses

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Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities

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Recombinant adeno-associated viral vectors are deficient in provoking a DNA damage response

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H2AX is required for cell cycle arrest via the p53/p21 pathway

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C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

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Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6.

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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

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Centrosomes split in the presence of impaired DNA integrity during mitosis

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

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Viral transport of DNA damage that mimics a stalled replication fork

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Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells.

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The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction

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Centrosome hyperamplification and chromosomal damage after exposure to radiation

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Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol

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Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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Cyclin-dependent kinase control of centrosome duplication

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Identification of a human mitotic checkpoint gene: hsMAD2

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Using or abusing: viruses and the cellular DNA damage response

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DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function

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Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

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A role for centrin 3 in centrosome reproduction

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Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins

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ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

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ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

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Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

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DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

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A possible role for centrosome overduplication in radiation-induced cell death

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Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53.

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