(Q39741170)

14 September 2017

Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production (English)

1 reference

14 September 2017

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2

C Ronald Kahn

1 reference

14 September 2017

Simon J Fisher

1

1 reference

PMCID

151923

14 September 2017

language of work or name

English

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publication date

1 February 2003

1 reference

Journal of Clinical Investigation

14 September 2017

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14 September 2017

111

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14 September 2017

463-468

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14 September 2017

4

1 reference

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Renal gluconeogenesis: its importance in human glucose homeostasis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Mechanisms of fatty acid-induced inhibition of glucose uptake

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Operation of Randle's cycle in patients with NIDDM

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Production of insulin resistance by hyperinsulinaemia in man.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Metabolic consequences of prolonged hyperinsulinemia in humans. Evidence for induction of insulin insensitivity

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151923

Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog

20 August 2018

1 reference

12 December 2020

Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin

1 reference

12 December 2020

Contribution of muscle and liver to glucose-fatty acid cycle in humans

1 reference

12 December 2020

A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon

1 reference

12 December 2020

Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans

1 reference

12 December 2020

Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI16426

1 reference

14 September 2017

1 reference

14 September 2017

1 reference

PMCID

151923