(Q39783612)

14 September 2017

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species (English)

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14 September 2017

reactive oxygen species

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J-J Lee

1

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14 September 2017

J-H Lee

2

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14 September 2017

Y-G Ko

3

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14 September 2017

S I Hong

4

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14 September 2017

J-S Lee

5

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14 September 2017

language of work or name

English

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publication date

26 October 2009

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14 September 2017

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14 September 2017

29

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14 September 2017

4

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14 September 2017

561-575

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https://scigraph.springernature.com/pub.10.1038/onc.2009.355

14 September 2017

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cites work

Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Mitochondria, oxidants, and aging

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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Dissecting the senescence-like program in tumor cells activated by Ras signaling

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Suppressing cancer: the importance of being senescent.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Bcl-2 activates a programme of premature senescence in human carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Suppression of p53-dependent senescence by the JNK signal transduction pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Bcl2's flexible loop domain regulates p53 binding and survival

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Novel role for JNK as a stress-activated Bcl2 kinase

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

31 March 2020

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Molecular genetic approaches to the study of cellular senescence

31 March 2020

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Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

Inactivation of Bcl-2 by phosphorylation

31 March 2020

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The serial cultivation of human diploid cell strains

31 March 2020

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Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes

31 March 2020

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p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells

31 March 2020

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Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.355

p21WAF/CIP1/SDI1 is upregulated due to increased mRNA stability during hydroxyurea-induced senescence of human fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Influence of induced reactive oxygen species in p53-mediated cell fate decisions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Conformation of the Bax C-terminus regulates subcellular location and cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Differential regulation and properties of MAPKs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Ink4a/Arf links senescence and aging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

AP-1 as a regulator of cell life and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Bcl-2 promotes premature senescence induced by oncogenic Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

MAP kinases and the control of nuclear events

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Caspase independence of radio-induced cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.355

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.355

1 reference

14 September 2017

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