(Q40202977)

18 September 2017

title

Dissecting the senescence-like program in tumor cells activated by Ras signaling (English)

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18 September 2017

Teeru Bihani

1

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18 September 2017

Agustin Chicas

series ordinal

2

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18 September 2017

Crystal Pui-Kwan Lo

series ordinal

3

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18 September 2017

Athena W Lin

series ordinal

4

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18 September 2017

language of work or name

English

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publication date

29 November 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

issue

4

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18 September 2017

page(s)

2666-2675

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Can targeting apoptosis resolve the cancer saga?

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Differentiation therapy of human cancer: basic science and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Chemotherapy response and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Apoptotic pathways and therapy resistance in human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The serial cultivation of human diploid cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Telomeres and senescence: the history, the experiment, the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Molecular pathogenesis of aging and cancer: are telomeres and telomerase the connection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Telomeres and human disease: ageing, cancer and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Role of ceramide in cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Cellular senescence: mitotic clock or culture shock?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Oxidative DNA damage and senescence of human diploid fibroblast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Hallmarks of senescence in carcinogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The Ras superfamily at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Three human transforming genes are related to the viral ras oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Oxidative stress is the new stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The RB and p53 pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Growth suppression by p16ink4 requires functional retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

p21--negative regulator of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The senescent side of tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The RAS signal transduction pathway and its role in radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

EGF effects on p53 in MDA-468 human breast cancer cells: implications for G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Mutations and altered expression of p16INK4 in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608127200

21 January 2018

Identifiers

DOI

10.1074/JBC.M608127200

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18 September 2017

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