(Q36226739)

12 August 2017

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title

Apoptotic pathways and therapy resistance in human malignancies (English)

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12 August 2017

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Boris Zhivotovsky

3

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author name string

Kristina Viktorsson

series ordinal

1

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12 August 2017

Rolf Lewensohn

series ordinal

2

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12 August 2017

publication date

1 January 2005

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Advances in Cancer Research

12 August 2017

published in

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12 August 2017

volume

94

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12 August 2017

page(s)

143-196

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Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

12 August 2017

cites work

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An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer

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The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway

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Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

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Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

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Hsp27 negatively regulates cell death by interacting with cytochrome c.

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Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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7 January 2021

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

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7 January 2021

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.

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7 January 2021

Predictive value of P53, BCL-2, and BAX in advanced head and neck carcinoma

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7 January 2021

Peripheral benzodiazepine receptors and mitochondrial function

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7 January 2021

Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation

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7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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7 January 2021

Triggering and modulation of apoptosis by oxidative stress

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7 January 2021

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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7 January 2021

The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis.

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7 January 2021

Mitochondrial Membrane Potential in Living Cells

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression.

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7 January 2021

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

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7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 January 2021

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

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7 January 2021

Heat shock proteins--modulators of apoptosis in tumour cells

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7 January 2021

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

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7 January 2021

Signal transduction by the JNK group of MAP kinases

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7 January 2021

Death receptors in chemotherapy and cancer

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7 January 2021

Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation

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7 January 2021

The multiple roles of PTEN in tumor suppression

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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7 January 2021

JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery

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7 January 2021

ST1571: a paradigm for clinical trials of molecularly targeted agents

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity

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7 January 2021

Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells

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7 January 2021

Heat Shock Protein 72 Does Not Modulate Ionizing Radiation-Induced Apoptosis in U1810 Non-Small Cell Lung Carcinoma Cells

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7 January 2021

Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy

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7 January 2021

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

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7 January 2021

Human caspase 12 has acquired deleterious mutations

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7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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7 January 2021

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

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7 January 2021

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

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7 January 2021

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

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7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

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7 January 2021

p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

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7 January 2021

Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor

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7 January 2021

Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas.

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7 January 2021

Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients.

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7 January 2021

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

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7 January 2021

Lysosomes in cell death

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7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

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7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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7 January 2021

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

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7 January 2021

The ups and downs of MEK kinase interactions

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

Characterization of XIAP-deficient mice

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7 January 2021

Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line

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7 January 2021

Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis

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7 January 2021

Bcl-XL is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy

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7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

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7 January 2021

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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7 January 2021

Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.

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7 January 2021

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

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7 January 2021

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

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7 January 2021

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

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7 January 2021

Death and anti-death: tumour resistance to apoptosis

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7 January 2021

Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line.

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7 January 2021

Inhibition of death receptor signals by cellular FLIP

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7 January 2021

Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress

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7 January 2021

Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma

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7 January 2021

Identification of an alternative form of caspase-9 in human gastric cancer cell lines: a role of a caspase-9 variant in apoptosis resistance

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7 January 2021

Heat shock proteins as cellular lifeguards

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7 January 2021

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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7 January 2021

Differences in Expression of Pro-Caspases in Small Cell and Non-small Cell Lung Carcinoma

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7 January 2021

Defective caspase-3 relocalization in non-small cell lung carcinoma.

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7 January 2021

Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling

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7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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7 January 2021

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

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7 January 2021

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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7 January 2021

The role of Bcl-2 family members in tumorigenesis

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7 January 2021

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

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7 January 2021

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

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7 January 2021

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

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7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Structure, function and regulation of p63 and p73.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins

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7 January 2021

Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Apoptosis in the absence of caspase 3.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The inhibitors of apoptosis: there is more to life than Bcl2.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

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7 January 2021

Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor

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7 January 2021

Prostate-specific expression of Bax delivered by an adenoviral vector induces apoptosis in LNCaP prostate cancer cells

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Molecular mechanisms underlying the interaction between ZD1839 ('Iressa') and cisplatin/5-fluorouracil

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7 January 2021

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7

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7 January 2021

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

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7 January 2021

The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Functional regulation of p73 and p63: development and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Nuclear and mitochondrial apoptotic pathways of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

DNA damage-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Heat shock protein 70 is required for the survival of cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Regulation of cell death: the calcium-apoptosis link

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Hsp27 as a negative regulator of cytochrome C release

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Fatal liaisons of p53 with Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

A model for p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Heat-shock protein 70 antagonizes apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Negative regulation of the Apaf-1 apoptosome by Hsp70

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Lack of c-Jun activity increases survival to cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Integral role of Noxa in p53-mediated apoptotic response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Mechanism of XIAP-mediated inhibition of caspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

To die or not to die: how does p53 decide?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

A single BIR domain of XIAP sufficient for inhibiting caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Akt is activated in response to an apoptotic signal.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

p73-alpha is capable of inducing scotin and ER stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

PTEN signaling pathways in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Bid acts on the permeability transition pore complex to induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

Caspases: their intracellular localization and translocation during apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994004-9

7 January 2021

10.1016/S0065-230X(05)94004-9

Identifiers

DOI

1 reference

12 August 2017

1 reference