(Q35091138)

6 August 2017

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title

Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7. (English)

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6 August 2017

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Irina V Lebedeva

1

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6 August 2017

Zhao Zhong Su

series ordinal

2

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6 August 2017

Devanand Sarkar

series ordinal

3

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6 August 2017

Paul B Fisher

series ordinal

4

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6 August 2017

1 April 2003

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Seminars in Cancer Biology

6 August 2017

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6 August 2017

13

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6 August 2017

169-178

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6 August 2017

2

1 reference

A triploblast origin for Myxozoa?

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Non-viral vectors in cancer gene therapy: principles and progress

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Update on adenovirus and its vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

A system for the propagation of adenoviral vectors with genetically modified receptor specificities

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Targeted adenoviral vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Conditional gene targeting for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Prodrug-activating systems in suicide gene therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Gene therapy for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Strategies for immunotherapy of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Apoptosis in tumorigenesis and cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Checkpoints: How to activate p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The role of p53-target genes in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

P53 gene mutations: case study of a clinical marker for solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Genetic mechanisms of tumor suppression by the human p53 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Development and validation of sensitive assays to quantitate gene expression after p53 gene therapy and paclitaxel chemotherapy using in vivo dosing in tumor xenograft models

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Aerosol delivery of PEI-p53 complexes inhibits B16-F10 lung metastases through regulation of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Contribution of CD95 ligand-induced neutrophil infiltration to the bystander effect in p53 gene therapy for human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

CT-guided intratumoral gene therapy in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type. P53 (Ad-p53)

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenoviral-mediated p53 gene transfer to non-small cell lung cancer through endobronchial injection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Long term follow-up of patients with recurrent ovarian cancer after Ad p53 gene replacement with SCH 58500

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Ad5CMVp53 gene therapy for locally advanced prostate cancer--where do we stand?

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenoviral vector-mediated gene transfer: timing of wild-type p53 gene expression in vivo and effect of tumor transduction on survival in a rat glioma brachytherapy model.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Detection of p53 alterations in human astrocytomas using frozen tissue sections for the polymerase chain reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Predicting response to cancer chemotherapy: the role of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

New insights into p53 regulation and gene therapy for cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Cancer gene therapy mediated by CTS1, a p53 derivative: advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The melanoma differentiation associated gene mda-7 suppresses cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Loss of MDA-7 expression with progression of melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900134-7

7 January 2021

10.1016/S1044-579X(02)00134-7

Identifiers

DOI

1 reference

6 August 2017

1 reference