(Q34286570)

1 August 2017

title

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts (English)

1 reference

1 August 2017

author

Julia A Newton Bishop

11

object named as

Julia Newton-Bishop

1 reference

1 August 2017

Thomas J Huot

1

1 reference

1 August 2017

Janice Rowe

2

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1 August 2017

Mark Harland

3

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1 August 2017

Sarah Drayton

4

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1 August 2017

Sharon Brookes

5

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1 August 2017

Chandra Gooptu

6

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1 August 2017

Patricia Purkis

7

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1 August 2017

Mike Fried

8

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1 August 2017

Veronique Bataille

9

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1 August 2017

Eiji Hara

10

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1 August 2017

Gordon Peters

12

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1 August 2017

language of work or name

English

0 references

publication date

1 December 2002

1 reference

Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

volume

22

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1 August 2017

issue

23

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1 August 2017

page(s)

8135-8143

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The serial cultivation of human diploid cell strains

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

6 July 2018

1 reference

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Immortalisation and transformation revisited

6 July 2018

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The INK4a/ARF network in tumour suppression

6 July 2018

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A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

6 July 2018

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

6 July 2018

1 reference

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Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

6 July 2018

1 reference

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

6 July 2018

1 reference

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

6 July 2018

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Genes involved in senescence and immortalization

6 July 2018

1 reference

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Cellular senescence: mitotic clock or culture shock?

6 July 2018

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PML is induced by oncogenic ras and promotes premature senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Regulation of p53 stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Mutation testing in melanoma families: INK4A, CDK4 and INK4D

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

The INK4A/ARF locus and its two gene products

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

6 July 2018

1 reference

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High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Senescence of human fibroblasts induced by oncogenic Raf.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

p14ARF links the tumour suppressors RB and p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Regulation of p53 stability by Mdm2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Production of high-titer helper-free retroviruses by transient transfection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

p16(Ink4a) in melanocyte senescence and differentiation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Mutation screening of the CDKN2A promoter in melanoma families.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

The p16INK4a/CDKN2A tumor suppressor and its relatives.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Role of the INK4a locus in tumor suppression and cell mortality.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134058

Ankyrin for clues about the function of p16INK4a

28 October 2018

1 reference

12 December 2020

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

1 reference

12 December 2020

Risky immortalization by telomerase

1 reference

12 December 2020

Genetic heterogeneity in familial malignant melanoma

1 reference

12 December 2020

p16INK4A and p15INK4B gene deletions in primary leukemias

1 reference

12 December 2020

Germline Mutations of the CDKN2 Gene in UK Melanoma Families

1 reference

12 December 2020

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

12 December 2020

10.1128/MCB.22.23.8135-8143.2002

Identifiers

DOI

1 reference

1 August 2017

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1 August 2017

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