(Q39797559)

14 September 2017

TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity (English)

1 reference

14 September 2017

Siqin Wu

1

1 reference

14 September 2017

Anne Hultquist

2

1 reference

14 September 2017

Per Hydbring

3

1 reference

14 September 2017

Cihan Cetinkaya

4

1 reference

14 September 2017

Fredrik Oberg

5

1 reference

14 September 2017

Lars-Gunnar Larsson

6

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14 September 2017

language of work or name

English

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publication date

17 September 2009

1 reference

Experimental Cell Research

14 September 2017

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14 September 2017

315

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14 September 2017

18

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14 September 2017

3099-3111

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Transcriptional regulation and transformation by Myc proteins

14 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The Myc/Max/Mad network and the transcriptional control of cell behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The proto-oncogene c-myc in hematopoietic development and leukemogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The Mad side of the Max network: antagonizing the function of Myc and more.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Genomic targets of the human c-Myc protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The logic of TGFbeta signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

TGF-beta signaling: positive and negative effects on tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Interferon gamma abrogates the differentiation block in v-myc-expressing U-937 monoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The inducible lac operator-repressor system is functional in mammalian cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Analysis of the DNA-binding activities of Myc/Max/Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Cellular senescence: when bad things happen to good cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Transforming growth factor-beta signaling in normal and malignant hematopoiesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Intrinsic tumour suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

c-MYC: more than just a matter of life and death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Modelling Myc inhibition as a cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

Non-transcriptional control of DNA replication by c-Myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.09.009

10.1016/J.YEXCR.2009.09.009

7 January 2021

Identifiers

DOI

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14 September 2017

1 reference