(Q40006122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells (English)

1 reference

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3 January 2020

4

1 reference

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3 January 2020

author name string

S Horn

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

U Bergholz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

M Jücker

3

1 reference

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3 January 2020

L Trümper

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

C Stocking

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

J Bäsecke

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

language of work or name

English

0 references

publication date

3 March 2008

1 reference

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3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

issue

29

1 reference

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3 January 2020

page(s)

4096-4106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

3 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

The PIK3CA gene is mutated with high frequency in human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Cancer-specific mutations in PIK3CA are oncogenic in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Assessment of somatic mutations in phosphatidylinositol 3-kinase gene in human lymphoma and acute leukaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Genetics of myeloid malignancies: pathogenetic and clinical implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

31 March 2020

Role of FLT3 in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

The proto-oncogene c-myc in hematopoietic development and leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Absence of hot spot mutations of the PIK3CA gene in acute myeloid leukaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Functional analysis of PIK3CA gene mutations in human colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Mutations of PIK3CA in gastric adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Antileukemic activity of rapamycin in acute myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Hyperactive Ras in developmental disorders and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Survival of acute myeloid leukemia cells requires PI3 kinase activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.40

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18317450%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 January 2020

1000852911

0 references

1 reference