(Q40023259)

16 September 2017

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. (English)

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16 September 2017

Erik Sahai

2

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author name string

Sophie Pinner

series ordinal

1

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16 September 2017

20 January 2008

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16 September 2017

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16 September 2017

10

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16 September 2017

127-137

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16 September 2017

2

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https://scigraph.springernature.com/pub.10.1038/ncb1675

16 September 2017

0 references

cites work

Cell migration in 3D matrix

1 reference

Signaling pathways controlling primordial germ cell migration in zebrafish.

21 January 2018

1 reference

Reassembly of contractile actin cortex in cell blebs

21 January 2018

1 reference

Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow.

21 January 2018

1 reference

Tumour-cell invasion and migration: diversity and escape mechanisms

21 January 2018

1 reference

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

21 January 2018

1 reference

Tumor cell migration in three dimensions

21 January 2018

1 reference

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

Rocks: multifunctional kinases in cell behaviour

21 January 2018

1 reference

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo

21 January 2018

1 reference

Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway

21 January 2018

1 reference

A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion

21 January 2018

1 reference

RhoE function is regulated by ROCK I-mediated phosphorylation

21 January 2018

1 reference

RhoE binds to ROCK I and inhibits downstream signaling

21 January 2018

1 reference

PDK1, the master regulator of AGC kinase signal transduction

21 January 2018

1 reference

Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

21 January 2018

1 reference

Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.

21 January 2018

1 reference

Differential transmission of actin motion within focal adhesions

21 January 2018

1 reference

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

21 January 2018

1 reference

Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

21 January 2018

1 reference

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

1 reference

Illuminating the metastatic process

21 January 2018

1 reference

Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.

21 January 2018

1 reference

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion

21 January 2018

1 reference

The Rho kinases I and II regulate different aspects of myosin II activity

21 January 2018

1 reference

Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis

21 January 2018

1 reference

Dynamics of RhoA and ROKalpha translocation in single living cells

21 January 2018

1 reference

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

21 January 2018

1 reference

Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells

21 January 2018

1 reference

Essential role of PDK1 in regulating endothelial cell migration

21 January 2018

1 reference

3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases

21 January 2018

1 reference

Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration

21 January 2018

1 reference

Genomic analysis of metastasis reveals an essential role for RhoC

21 January 2018

1 reference

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

21 January 2018

1 reference

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

21 January 2018

1 reference

21 January 2018

RHO-GTPases and cancer

1 reference

Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.

21 January 2018

1 reference

Blebbing of Dictyostelium cells in response to chemoattractant

21 January 2018

1 reference

Proteolytic and non-proteolytic migration of tumour cells and leucocytes

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Role of vinculin in regulating focal adhesion turnover

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCB1675

1 reference

16 September 2017

1 reference

PubMed ID

18204440