(Q40028531)

16 September 2017

title

Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors (English)

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16 September 2017

4

Gerhard Müller-Newen

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author name string

Silke Metz

series ordinal

1

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16 September 2017

Gudrun Naeth

series ordinal

2

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16 September 2017

Peter C Heinrich

series ordinal

3

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16 September 2017

language of work or name

English

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publication date

3 January 2008

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

10

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16 September 2017

page(s)

5985-5995

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Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis

16 September 2017

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1 reference

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A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.

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Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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21 January 2018

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The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor

21 January 2018

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A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor

21 January 2018

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Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation

21 January 2018

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The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex

21 January 2018

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Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro

21 January 2018

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The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling

21 January 2018

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Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector.

21 January 2018

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Production of hybridoma growth factor by human monocytes.

21 January 2018

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Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization

21 January 2018

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Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

21 January 2018

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LIF and OM directly interact with a soluble form of gp130, the IL-6 receptor signal transducing subunit

21 January 2018

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Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.

21 January 2018

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Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.

21 January 2018

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An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

21 January 2018

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Molecular phylogeny within type I cytokines and their cognate receptors

21 January 2018

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Role of cytokines in rheumatoid arthritis

21 January 2018

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Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis

21 January 2018

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Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides

21 January 2018

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Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

21 January 2018

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In vitro evaluation of leukemia inhibitory factor receptor antagonists as candidate therapeutics for inflammatory arthritis.

21 January 2018

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Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

21 January 2018

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Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions

21 January 2018

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The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture.

21 January 2018

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Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancy

21 January 2018

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Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M706610200

1 reference

16 September 2017

1 reference