(Q40053611)

16 September 2017

title

6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. (English)

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16 September 2017

Maria Gomez-Lazaro

1

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16 September 2017

Maria F Galindo

2

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16 September 2017

Caoimhín G Concannon

3

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16 September 2017

Miguel F Segura

4

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16 September 2017

Francisco J Fernandez-Gomez

5

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16 September 2017

Nuria Llecha

6

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16 September 2017

Joan X Comella

7

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16 September 2017

Jochen H M Prehn

8

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16 September 2017

Joaquin Jordan

9

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16 September 2017

language of work or name

English

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publication date

6 November 2007

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Journal of Neurochemistry

16 September 2017

published in

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16 September 2017

volume

104

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16 September 2017

issue

6

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16 September 2017

page(s)

1599-1612

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

16 September 2017

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Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

21 January 2018

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p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

21 January 2018

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons

21 January 2018

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BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development

21 January 2018

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Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

21 January 2018

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Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria

21 January 2018

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Chromaffin cell death induced by 6-hydroxydopamine is independent of mitochondrial swelling and caspase activation.

21 January 2018

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

21 January 2018

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Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells

21 January 2018

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Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells

21 January 2018

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Biochemical characterization of the mitochondrial permeability transition in isolated forebrain mitochondria

21 January 2018

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Excitotoxic injury to mitochondria isolated from cultured neurons.

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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21 January 2018

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21 January 2018

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6-Hydroxydopamine increases the level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats

21 January 2018

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Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress

21 January 2018

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21 January 2018

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Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.

21 January 2018

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The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

21 January 2018

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Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.

21 January 2018

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Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis

21 January 2018

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Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

21 January 2018

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Control of mitochondrial permeability by Bcl-2 family members

21 January 2018

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Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways

21 January 2018

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Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging

21 January 2018

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Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation

21 January 2018

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

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Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes.

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

21 January 2018

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Neuronal apoptosis: BH3-only proteins the real killers?

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

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Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.05115.X

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2007.05115.X

10.1111/J.1471-4159.2007.05115.X

21 January 2018

Identifiers

DOI

1 reference

16 September 2017

1 reference