(Q40095134)

17 September 2017

title

Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity (English)

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17 September 2017

Sokol V Todi

1

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author name string

Mario N Laco

2

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17 September 2017

Brett J Winborn

3

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17 September 2017

Sue M Travis

4

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17 September 2017

Hsiang M Wen

5

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17 September 2017

Henry L Paulson

6

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17 September 2017

language of work or name

English

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publication date

10 August 2007

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Journal of Biological Chemistry

17 September 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

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17 September 2017

volume

282

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17 September 2017

issue

40

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17 September 2017

page(s)

29348-29358

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Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

17 September 2017

cites work

1 reference

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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

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Characterisation of the unstable expanded CAG repeat in the MJD1 gene in four Brazilian families of Portuguese descent with Machado-Joseph disease

21 January 2018

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Glutamine repeats and neurodegeneration

21 January 2018

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The pathogenesis of spinocerebellar ataxia

21 January 2018

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Trinucleotide repeats: mechanisms and pathophysiology

21 January 2018

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Polyglutamine disease and neuronal cell death.

21 January 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord.

21 January 2018

1 reference

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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M704126200

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain

21 January 2018

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Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease

21 January 2018

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Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions

21 January 2018

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Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.

21 January 2018

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A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

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Mechanism and function of deubiquitinating enzymes

21 January 2018

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Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.

21 January 2018

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Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

21 January 2018

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

21 January 2018

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An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments

21 January 2018

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Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.

21 January 2018

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

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C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704126200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704126200

1 reference

17 September 2017

1 reference