(Q40393907)

20 September 2017

title

Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3. (English)

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20 September 2017

author name string

Sarah J Shoesmith Berke

1

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20 September 2017

Yaohui Chai

2

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20 September 2017

Ginger L Marrs

3

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20 September 2017

Hsiang Wen

4

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20 September 2017

Henry L Paulson

5

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20 September 2017

language of work or name

English

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publication date

21 July 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

36

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20 September 2017

page(s)

32026-32034

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

20 September 2017

cites work

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21 January 2018

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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

21 January 2018

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Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

21 January 2018

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Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

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Polyglutamines placed into context

21 January 2018

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Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

21 January 2018

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An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients.

21 January 2018

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21 January 2018

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Deubiquitinating enzymes: their diversity and emerging roles

21 January 2018

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Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

21 January 2018

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Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway

21 January 2018

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The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation

21 January 2018

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Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

21 January 2018

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Protein regulation by monoubiquitin

21 January 2018

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A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination

21 January 2018

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The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination

21 January 2018

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

21 January 2018

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A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins

21 January 2018

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Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation

21 January 2018

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Molecular clearance of ataxin-3 is regulated by a mammalian E4

21 January 2018

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Allele-specific silencing of dominant disease genes

21 January 2018

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21 January 2018

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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

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Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

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Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

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21 January 2018

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

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Structural modeling of ataxin-3 reveals distant homology to adaptins

21 January 2018

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An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.

21 January 2018

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Structural instability and fibrillar aggregation of non-expanded human ataxin-3 revealed under high pressure and temperature

21 January 2018

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Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail

21 January 2018

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Non-traditional functions of ubiquitin and ubiquitin-binding proteins

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.

21 January 2018

1 reference

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Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities

21 January 2018

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

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Promyelocytic leukemia protein is redistributed during the formation of intranuclear inclusions independent of polyglutamine expansion: an immunohistochemical study on Marinesco bodies

21 January 2018

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Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease

21 January 2018

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Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506084200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506084200

1 reference

20 September 2017

1 reference