(Q40120458)

17 September 2017

title

Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha (English)

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17 September 2017

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Vijay Yanamadala

1

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17 September 2017

Hideyuki Negoro

2

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17 September 2017

Lakshman Gunaratnam

3

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17 September 2017

Tianqing Kong

4

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17 September 2017

Bradley M Denker

5

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17 September 2017

language of work or name

English

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publication date

12 June 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

33

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17 September 2017

page(s)

24352-24363

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The machinery of programmed cell death.

17 September 2017

cites work

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Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy

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Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor

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Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells

21 January 2018

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Galpha(s) sensitizes human SH-SY5Y cells to apoptosis independently of the protein kinase A pathway

21 January 2018

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Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12.

21 January 2018

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The transforming activity of activated G alpha 12.

21 January 2018

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Galpha12 regulates epithelial cell junctions through Src tyrosine kinases

21 January 2018

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Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells

21 January 2018

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Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function

21 January 2018

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G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

21 January 2018

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A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

21 January 2018

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Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1

21 January 2018

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G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity

21 January 2018

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Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

21 January 2018

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Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?

21 January 2018

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21 January 2018

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PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

21 January 2018

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Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor

21 January 2018

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Disruption of epithelial cell-matrix interactions induces apoptosis

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

21 January 2018

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JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2.

21 January 2018

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The two faces of NFkappaB in cell survival responses

21 January 2018

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Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha

21 January 2018

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Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

21 January 2018

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

21 January 2018

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Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity

21 January 2018

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N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors.

21 January 2018

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Proliferation-specific genes activated by Galpha(12): a role for PDGFRalpha and JAK3 in Galpha(12)-mediated cell proliferation

21 January 2018

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Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.

21 January 2018

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A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion

21 January 2018

1 reference

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The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis

21 January 2018

1 reference

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Osteoblast and osteocyte apoptosis associated with androgen action in bone: requirement of increased Bax/Bcl-2 ratio

21 January 2018

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Activation of pro-apoptotic cascade by dopamine in renal epithelial cells is fully dependent on hydrogen peroxide generation by monoamine oxidases

21 January 2018

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Regulatory roles of JNK in programmed cell death

21 January 2018

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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

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A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

21 January 2018

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Apoptosis and loss of renal tissue in polycystic kidney diseases

21 January 2018

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Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

21 January 2018

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Polycystin-1L2 is a novel G-protein-binding protein

21 January 2018

1 reference

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The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro

21 January 2018

1 reference

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

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Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelial cyst formation

21 January 2018

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The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways

21 January 2018

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Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins

21 January 2018

1 reference

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Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Galpha12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Differential regulation of Jun N-terminal kinase and p38MAP kinase by Galpha12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Current insights into the regulation of programmed cell death by NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702804200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702804200

1 reference

17 September 2017

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