(Q40171642)

English

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function

scientific article published on 12 February 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

based on heuristic

inferred from title

invasive ductal carcinoma

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pancreatic ductal adenocarcinoma

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pancreatic ductal carcinoma

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author name string

Schniewind B

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Groth S

2

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Europe PubMed Central

PubMed publication ID

18 September 2017

Sebens Müerköster S

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Sipos B

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Schäfer H

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Kalthoff H

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Fändrich F

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Ungefroren H

8

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

language of work or name

0 references

publication date

12 February 2007

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Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

26

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Europe PubMed Central

PubMed publication ID

18 September 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

4850-4862

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Europe PubMed Central

PubMed publication ID

18 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210272

0 references

Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition

1 reference

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Thrombospondins as matricellular modulators of cell function

1 reference

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Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein

1 reference

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7 January 2021

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Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells

1 reference

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7 January 2021

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A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

1 reference

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7 January 2021

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The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

1 reference

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7 January 2021

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TGF-beta signaling in tumor suppression and cancer progression

1 reference

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

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7 January 2021

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Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.

1 reference

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7 January 2021

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TGF-?-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system

1 reference

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7 January 2021

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Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.

1 reference

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7 January 2021

based on heuristic

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Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

1 reference

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7 January 2021

based on heuristic

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Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

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Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Pro-metastasis function of TGFbeta mediated by the Smad pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant ductal lesions in the pancreas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

The functions of thrombospondin-1 and-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

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TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

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Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor-beta in breast cancer: a working hypothesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Radiosensitivity with Par-4 expression in prostate cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

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Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

1 reference

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7 January 2021

based on heuristic

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Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Antitumor activity of ALK1 in pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta and epithelial-to-mesenchymal transitions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210272

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1210272

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

0 references

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