(Q40172413)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

1 reference

7

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25 December 2019

Ugo Testa

14

1 reference

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25 December 2019

Eleonora Petrucci

1

1 reference

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25 December 2019

Luca Pasquini

2

1 reference

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25 December 2019

Ernestina Saulle

4

1 reference

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25 December 2019

Roberta Riccioni

6

1 reference

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25 December 2019

8

Gianluigi Ferretti

1 reference

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25 December 2019

author name string

Alessia Petronelli

3

1 reference

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25 December 2019

Gualtiero Mariani

5

1 reference

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25 December 2019

Pieluigi Benedetti-Panici

9

1 reference

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25 December 2019

Francesco Cognetti

10

1 reference

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25 December 2019

Giovanni Scambia

11

1 reference

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25 December 2019

Robin Humphreys

12

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25 December 2019

Cesare Peschle

13

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25 December 2019

language of work or name

English

0 references

publication date

9 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

105

1 reference

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25 December 2019

issue

2

1 reference

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25 December 2019

page(s)

481-492

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

Dysregulation of apoptosis in cancer

25 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

The biochemistry of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Multiple cell death pathways as regulators of tumour initiation and progression.

7 January 2021

1 reference

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Toxic proteins released from mitochondria in cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

IAP proteins: blocking the road to death's door

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Targeting XIAP for the treatment of malignancy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Development of Peptidomimetics Targeting IAPs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Perturbation of the tumor necrosis factor--related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Survivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2007.01.011

10.1016/J.YGYNO.2007.01.011

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17292950%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference