(Q40187542)

English

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics

scientific article published on January 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

prion protein family

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

Giuseppe Legname

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Stanley B. Prusiner

7

object named as

Stanley B Prusiner

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

8

object named as

Fred E Cohen

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Barnaby C H May

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Julie A Zorn

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Juanita Witkop

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

John Sherrill

4

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18 September 2017

Andrew C Wallace

5

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18 September 2017

language of work or name

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publication date

1 January 2007

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18 September 2017

Journal of Medicinal Chemistry

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18 September 2017

50

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18 September 2017

1

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18 September 2017

65-73

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PubMed publication ID

18 September 2017

A cellular gene encodes scrapie PrP 27-30 protein

1 reference

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PD 116,948, a highly selective A1 adenosine receptor antagonist

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Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

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CARE-LASS (calcein-release-assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity

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Linking solubility and permeability assays for maximum throughput and reproducibility.

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Identifiers

10.1021/JM061045Z

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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