(Q40196292)

18 September 2017

title

Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416. (English)

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18 September 2017

main subject

acute myeloid leukemia

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12

Carsten Bokemeyer

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18 September 2017

Sonja Loges

1

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18 September 2017

Heike Tinnefeld

2

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18 September 2017

Anja Metzner

3

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18 September 2017

Manfred Jücker

4

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18 September 2017

Martin Butzal

5

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18 September 2017

Melanie Bruweleit

6

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18 September 2017

Uta Fischer

7

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18 September 2017

Elena Draab

8

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18 September 2017

Gunter Schuch

9

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18 September 2017

Anne Marie O'-Farrel

10

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18 September 2017

Dieter Kurt Hossfeld

11

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18 September 2017

Walter Fiedler

13

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18 September 2017

publication date

1 December 2006

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18 September 2017

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18 September 2017

volume

47

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18 September 2017

issue

12

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18 September 2017

page(s)

2601-2609

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Angiogenesis in cancer, vascular, rheumatoid and other disease

18 September 2017

cites work

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Mechanisms of angiogenesis

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Vascular-specific growth factors and blood vessel formation

21 January 2018

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Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

21 January 2018

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Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

21 January 2018

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https://api.crossref.org/works/10.1080%2F10428190600948253

SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

21 January 2018

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Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma

21 January 2018

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Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Characterization of the human STAT5A and STAT5B promoters: evidence of a positive and negative mechanism of transcriptional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190600948253

10.1080/10428190600948253

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference