(Q40223201)

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Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

scientific article published on 5 October 2006

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20 December 2019

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist (English)

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20 December 2019

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20 December 2019

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20 December 2019

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20 December 2019

Geoffrey Lilley Smith

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Geoffrey L Smith

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20 December 2019

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Pilar Najarro

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20 December 2019

James E Pease

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20 December 2019

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5 October 2006

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20 December 2019

Journal of Biological Chemistry

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20 December 2019

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20 December 2019

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20 December 2019

36652-36661

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20 December 2019

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Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

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CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease.

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Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease.

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Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309

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21 January 2018

Identification of CCR8, the receptor for the human CC chemokine I-309

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21 January 2018

Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor

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21 January 2018

HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines

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21 January 2018

The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8

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21 January 2018

A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

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21 January 2018

The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody

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21 January 2018

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

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21 January 2018

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.

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21 January 2018

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

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Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.

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21 January 2018

Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.

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21 January 2018

The human cytokine I-309 is a monocyte chemoattractant

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21 January 2018

Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors

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21 January 2018

The genome sequence of Yaba-like disease virus, a yatapoxvirus

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21 January 2018

Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.

1 reference

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21 January 2018

The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation

1 reference

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21 January 2018

The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation

1 reference

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21 January 2018

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

1 reference

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21 January 2018

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle

1 reference

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21 January 2018

The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8

1 reference

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21 January 2018

Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells

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21 January 2018

RANTES and MIP-1alpha activate stats in T cells

1 reference

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21 January 2018

Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes

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21 January 2018

beta-arrestins regulate interleukin-8-induced CXCR1 internalization

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21 January 2018

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

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21 January 2018

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

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21 January 2018

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

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21 January 2018

Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4

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Pharmacological characterization of the chemokine receptor, CCR5.

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Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.

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CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

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Identifiers

10.1074/JBC.M605584200

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17023422%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17023422%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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