(Q40234601)

English

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

scientific article published on 7 September 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 September 2017

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Alan N Engelman

5

object named as

Alan Engelman

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Peter Cherepanov

4

object named as

Peter Cherepanov

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Shaila Rahman

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Richard Lu

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Nick Vandegraaff

3

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Europe PubMed Central

PubMed publication ID

18 September 2017

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publication date

7 September 2006

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Europe PubMed Central

PubMed publication ID

18 September 2017

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Europe PubMed Central

PubMed publication ID

18 September 2017

357

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Europe PubMed Central

PubMed publication ID

18 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

79-90

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

1 reference

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HIV-1 infection requires a functional integrase NLS.

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Correct integration of retroviral DNA in vitro

1 reference

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Targeting survival: integration site selection by retroviruses and LTR-retrotransposons

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Retroviral DNA integration directed by HIV integration protein in vitro

1 reference

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7 January 2021

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

1 reference

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7 January 2021

A quantitative assay for HIV DNA integration in vivo

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Acetylation of HIV-1 integrase by p300 regulates viral integration

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Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome

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Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat Ends

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Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

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High-level expression of active HIV-1 integrase from a synthetic gene in human cells

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

1 reference

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

1 reference

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7 January 2021

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

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7 January 2021

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

1 reference

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A role for LEDGF/p75 in targeting HIV DNA integration

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Intracellular transport of human immunodeficiency virus type 1 integrase

1 reference

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7 January 2021

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

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The ups and downs of gene expression and retroviral DNA integration

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Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro

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The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution

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Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase

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Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

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Retroviral cDNA integration: stimulation by HMG I family proteins

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Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import

1 reference

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7 January 2021

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

1 reference

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7 January 2021

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication

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7 January 2021

Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase

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7 January 2021

Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase

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7 January 2021

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication

1 reference

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7 January 2021

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75.

1 reference

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7 January 2021

Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions

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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

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Genome-wide analyses of avian sarcoma virus integration sites

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Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

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Reversion of the lethal phenotype of an HIV-1 integrase mutant virus by overexpression of the same integrase mutant protein.

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HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle

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HIV-1 integration in the human genome favors active genes and local hotspots

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Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells

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Human cell proteins and human immunodeficiency virus DNA integration

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

1 reference

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Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication

1 reference

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

1 reference

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

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Transcription start regions in the human genome are favored targets for MLV integration

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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

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Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis.

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

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1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VIROL.2006.08.011

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

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