(Q40273672)

19 September 2017

title

Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants (English)

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19 September 2017

main subject

endometrial carcinoma

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Xavier Matias-Guiu Guia

8

object named as

Xavier Matias-Guiu

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19 September 2017

Xavier Dolcet

1

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19 September 2017

David Llobet

2

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19 September 2017

Mario Encinas

3

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19 September 2017

Judit Pallares

4

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19 September 2017

Albert Cabero

5

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19 September 2017

Joan Antoni Schoenenberger

6

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19 September 2017

Joan X Comella

7

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19 September 2017

language of work or name

English

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publication date

30 May 2006

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

issue

31

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19 September 2017

page(s)

22118-22130

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The development of proteasome inhibitors as anticancer drugs

19 September 2017

cites work

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NF-kappa B as a therapeutic target in multiple myeloma

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The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

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Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

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The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

21 January 2018

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NF-kappaB at the crossroads of life and death

21 January 2018

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Nuclear factor-kappaB: the enemy within

21 January 2018

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NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

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Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

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Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma.

21 January 2018

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NF-kB in development and progression of human cancer

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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

21 January 2018

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The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536.

21 January 2018

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

21 January 2018

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

21 January 2018

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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

21 January 2018

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Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells

21 January 2018

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The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.

21 January 2018

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

21 January 2018

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IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy

21 January 2018

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Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.

21 January 2018

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Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events

21 January 2018

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Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma

21 January 2018

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Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

21 January 2018

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Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.

21 January 2018

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Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

21 January 2018

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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

21 January 2018

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Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

21 January 2018

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

21 January 2018

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The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

21 January 2018

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

21 January 2018

1 reference

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Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601350200

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601350200

21 January 2018

Identifiers

DOI

10.1074/JBC.M601350200

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19 September 2017

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