(Q40275144)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase (English)

1 reference

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28 January 2020

1 reference

2

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28 January 2020

author name string

Lijun Yan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Rebecca Jones

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Julia Procter

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Yunhong Cao

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Richard F Lamb

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

language of work or name

English

0 references

publication date

25 May 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

28 January 2020

published in

1 reference

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28 January 2020

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

19793-19797

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

28 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Stimulation of gene induction and cell growth by the Ras effector Rlf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Structural basis for the unique biological function of small GTPase RHEB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600028200

21 January 2018

Identifiers

DOI

10.1074/JBC.C600028200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16728407%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference