(Q46785716)

25 December 2017

title

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast (English)

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25 December 2017

author name string

Jun Urano

1

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25 December 2017

Melissa J Comiso

2

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25 December 2017

Lea Guo

3

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25 December 2017

Paul-Joseph Aspuria

4

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25 December 2017

Roman Deniskin

5

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25 December 2017

Angel P Tabancay

6

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25 December 2017

Juran Kato-Stankiewicz

7

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25 December 2017

Fuyuhiko Tamanoi

8

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25 December 2017

language of work or name

English

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publication date

1 November 2005

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25 December 2017

published in

Molecular Microbiology

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25 December 2017

volume

58

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25 December 2017

page(s)

1074-1086

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25 December 2017

issue

4

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25 December 2017

The Rheb family of GTP-binding proteins

cites work

1 reference

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The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

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21 January 2018

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An unusual H-Ras mutant isolated from a human multiple myeloma line leads to transformation and factor-independent cell growth

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

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Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

21 January 2018

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Tandem affinity purification and identification of protein complex components.

21 January 2018

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

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Signaling by target of rapamycin proteins in cell growth control

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Dysregulation of the TSC-mTOR pathway in human disease

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Ras effectors and their role in mitogenesis and oncogenesis

21 January 2018

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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

21 January 2018

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Signal transduction from multiple Ras effectors

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Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

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Rheb binds and regulates the mTOR kinase

21 January 2018

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Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

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Rheb fills a GAP between TSC and TOR.

21 January 2018

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The expanding TOR signaling network

21 January 2018

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Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

21 January 2018

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Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

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Tuberous sclerosis complex: genetics to pathogenesis

21 January 2018

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Tuberous sclerosis complex: from Drosophila to human disease.

21 January 2018

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Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

21 January 2018

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Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe

21 January 2018

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 January 2018

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Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

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Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

21 January 2018

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The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

21 January 2018

1 reference

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The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

Structural basis for the unique biological function of small GTPase RHEB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2005.04877.X

10.1111/J.1365-2958.2005.04877.X

21 January 2018

Identifiers

DOI

1 reference

25 December 2017

PubMed ID

16262791

1 reference

25 December 2017