(Q40295769)

19 September 2017

title

Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein (English)

1 reference

19 September 2017

Louise C Serpell

2

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author name string

Wei Li

1

1 reference

19 September 2017

Wendy J Carter

3

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19 September 2017

David C Rubinsztein

4

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19 September 2017

James A Huntington

5

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19 September 2017

language of work or name

English

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publication date

4 April 2006

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

issue

23

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19 September 2017

page(s)

15916-15922

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

19 September 2017

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

21 January 2018

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Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

21 January 2018

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Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients

21 January 2018

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Cleavage pattern and emerging asymmetry of the mouse embryo.

21 January 2018

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

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Polyglutamines placed into context

21 January 2018

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Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

21 January 2018

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Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease

21 January 2018

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The hunt for huntingtin function: interaction partners tell many different stories

21 January 2018

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A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

21 January 2018

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The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

21 January 2018

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HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions

21 January 2018

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Structure of importin-beta bound to the IBB domain of importin-alpha

21 January 2018

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21 January 2018

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

21 January 2018

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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

21 January 2018

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The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

21 January 2018

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Comparison of ARM and HEAT protein repeats

21 January 2018

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Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

21 January 2018

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New approaches in molecular structure prediction

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A putative Drosophila homolog of the Huntington's disease gene

21 January 2018

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21 January 2018

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21 January 2018

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A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

21 January 2018

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Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 2. Solution stability and cooperativity of unfolding

21 January 2018

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Mutant protein in Huntington disease is resistant to proteolysis in affected brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511007200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511007200

Huntingtin associates with acidic phospholipids at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511007200

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511007200

21 January 2018

Identifiers

DOI

10.1074/JBC.M511007200

1 reference

19 September 2017

1 reference