(Q40299856)

19 September 2017

Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells (English)

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Human T-lymphotropic virus 1

19 September 2017

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author name string

Geetha Babu

1

1 reference

19 September 2017

Michael Waterfield

2

1 reference

19 September 2017

Mikyoung Chang

3

1 reference

19 September 2017

Xuefeng Wu

4

1 reference

19 September 2017

Shao-Cong Sun

5

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19 September 2017

language of work or name

English

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publication date

24 March 2006

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Journal of Biological Chemistry

19 September 2017

7

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based on heuristic

inferred from page(s)

published in

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19 September 2017

281

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19 September 2017

20

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19 September 2017

14041-14047

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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Seizing of T cells by human T-cell leukemia/lymphoma virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Activation of NF-kappaB by HTLV-I and implications for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Transducing signals from antigen receptors to nuclear factor kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Structure and transforming potential of the human cot oncogene encoding a putative protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

IkappaB kinase is an essential component of the Tpl2 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone

21 January 2018

1 reference

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Novel IKK inhibitors: beta-carbolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector

21 January 2018

1 reference

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Expression of the Tpl2/Cot oncogene in human T-cell neoplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Human T-cell leukemia virus type I and adult T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

Deregulation of NF-kappaB and its upstream kinases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512375200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512375200

1 reference

19 September 2017

1 reference