(Q40312032)

English

Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Delta24RGD.

scientific article published on 24 February 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Delta24RGD. (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

oncolytic virus

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

myotonic dystrophy

1 reference

based on heuristic

inferred from title

author name string

Majem M

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Cascallo M

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Bayo-Puxan N

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Mesia R

4

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Germa JR

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Alemany R

6

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

publication date

24 February 2006

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Cancer Gene Therapy

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

696-705

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700940

0 references

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

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Blood clearance rates of adenovirus type 5 in mice

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The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors.

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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

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Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

1 reference

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Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

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Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha

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Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

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Regulation of cell proliferation by the E2F transcription factors

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Role of E2F in cell cycle control and cancer

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The regulation of E2F by pRB-family proteins

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The Rb/E2F pathway and cancer

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Modulation of the specificity and activity of a cellular promoter in an adenoviral vector

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Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors.

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Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with e1 deleted

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Insulation of a conditionally expressed transgene in an adenoviral vector

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The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700940

21 January 2018

Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700940

21 January 2018

Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700940

21 January 2018

Insulators: many functions, many mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700940

21 January 2018

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

1 reference

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Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

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Retroviral-mediated gene transfer of human ornithine transcarbamylase into primary hepatocytes of spf and spf-ash mice

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Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.

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A simplified system for generating recombinant adenoviruses

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Impact of E1a modifications on tumor-selective adenoviral replication and toxicity.

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Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes

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Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma

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Infection of Mouse Liver by Human Adenovirus Type 5

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer

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21 January 2018

Adenovirus E1A under the control of heterologous promoters: wide variation in E1A expression levels has little effect on virus replication

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD').

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An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

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An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.CGT.7700940

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

ResearchGate publication ID

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