(Q40330281)

19 September 2017

Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. (English)

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19 September 2017

10

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19 September 2017

7

Patterson LH

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19 September 2017

9

McKeown SR

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19 September 2017

Yakkundi A

1

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19 September 2017

McErlane V

2

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19 September 2017

Murray M

3

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19 September 2017

McCarthy HO

4

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19 September 2017

Ward C

5

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19 September 2017

Hughes CM

6

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19 September 2017

Hirst DG

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19 September 2017

1 June 2006

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19 September 2017

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19 September 2017

13

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19 September 2017

6

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19 September 2017

598-605

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700933

19 September 2017

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cites work

Biological consequences of tumor hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Hypoxia-Specific Cytotoxins in Cancer Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Combining bioreductive drugs and radiation for the treatment of solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Tumour cytochrome P450 and drug activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

AQ4N: a new approach to hypoxia-activated cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

High levels of recombinant CYP3A4 expression in Chinese hamster ovary cells are modulated by coexpressed human P450 reductase and hemin supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

The expression and regulation of drug metabolism in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

CYP1A2 is expressed along with CYP1A1 in the human lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

Tirapazamine: prototype for a novel class of therapeutic agents targeting tumor hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Reoxygenation after single irradiation in rodent tumors of different types and sizes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700933

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700933

1 reference

Dimensions Publication ID

19 September 2017

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1 reference