(Q40335692)

19 September 2017

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione (English)

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19 September 2017

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2

Arthur I Cederbaum

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19 September 2017

Jingxiang Bai

1

1 reference

PubMed ID

16380384

19 September 2017

language of work or name

English

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publication date

27 December 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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19 September 2017

8

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19 September 2017

5128-5136

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Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Experimental liver cirrhosis induced by alcohol and iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

A soluble NH(2)-terminally truncated catalytically active form of rat cytochrome P450 2E1 targeted to liver mitochondria(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Oxidative damage during aging targets mitochondrial aconitase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

The mitochondrial permeability transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Adenovirus-mediated expression of Cu/Zn- or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Role of ultraviolet A-induced oxidative DNA damage in apoptosis via loss of mitochondrial membrane potential and caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Turnover studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Molecular Basis for the Transport of Cytochrome P450 2E1 to the Plasma Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510484200

21 January 2018

Identifiers

DOI

10.1074/JBC.M510484200

1 reference

19 September 2017

1 reference

PubMed ID

16380384