(Q40348451)

19 September 2017

title

Down-regulation of endogenous amyloid precursor protein processing due to cellular aging (English)

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19 September 2017

Andreas Kern

1

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19 September 2017

Birgit Roempp

2

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19 September 2017

Kai Prager

3

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19 September 2017

Jochen Walter

4

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19 September 2017

Christian Behl

5

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19 September 2017

language of work or name

English

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publication date

22 November 2005

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

issue

5

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19 September 2017

page(s)

2405-2413

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

19 September 2017

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21 January 2018

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21 January 2018

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N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro

21 January 2018

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

21 January 2018

1 reference

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

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Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

21 January 2018

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

21 January 2018

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Increased caveolin-1 expression in Alzheimer's disease brain

21 January 2018

1 reference

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Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age.

21 January 2018

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Dietary restriction counteracts age-related changes in cholesterol metabolism in the rat.

21 January 2018

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M505625200

1 reference

19 September 2017

1 reference