(Q40395130)

20 September 2017

title

Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression (English)

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20 September 2017

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Kuppuswamy M

1

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20 September 2017

Spencer JF

2

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20 September 2017

Doronin K

3

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20 September 2017

Tollefson AE

4

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20 September 2017

Wold WS

5

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20 September 2017

Toth K

6

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20 September 2017

publication date

1 November 2005

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20 September 2017

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20 September 2017

volume

12

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20 September 2017

issue

22

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20 September 2017

page(s)

1608-1617

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302581

20 September 2017

exact match

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cites work

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Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy

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An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated wnt signaling

21 January 2018

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Adenovirus early E4 genes in viral oncogenesis

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The role of adenovirus E4orf4 protein in viral replication and cell killing

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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A survey of telomerase activity in human cancer

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Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

21 January 2018

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A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo.

21 January 2018

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The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

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Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter

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A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells

21 January 2018

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Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity

21 January 2018

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Telomerase-specific replication-selective virotherapy for human cancer

21 January 2018

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Ad-mTERT-delta19, a conditional replication-competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in a cancer cell-specific manner

21 January 2018

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New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication

21 January 2018

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Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer

21 January 2018

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The E3-11.6-kDa adenovirus death protein (ADP) is required for efficient cell death: characterization of cells infected with adp mutants

21 January 2018

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Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants

21 January 2018

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Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

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Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

21 January 2018

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Telomeres and telomerase in normal and malignant haematopoietic cells

21 January 2018

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Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

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Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector

21 January 2018

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Functions and mechanisms of action of the adenovirus E3 proteins

21 January 2018

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Update on adenovirus and its vectors

21 January 2018

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7 January 2021

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302581

7 January 2021

A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302581

7 January 2021

Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302581

7 January 2021

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302581

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302581

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Dimensions Publication ID

20 September 2017

1034461984

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1 reference