(Q40448465)

English

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

apoptotic process

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Lukáš Čermák

3

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author name string

Konstantinos G Drosopoulos

1

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Europe PubMed Central

PubMed publication ID

20 September 2017

Michael L Roberts

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Takehiko Sasazuki

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Senji Shirasawa

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Ladislav Andera

6

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Europe PubMed Central

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20 September 2017

Alexander Pintzas

7

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Europe PubMed Central

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20 September 2017

language of work or name

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publication date

8 March 2005

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Europe PubMed Central

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20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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20 September 2017

280

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Europe PubMed Central

PubMed publication ID

20 September 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

22856-22867

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

The multistep nature of cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

The receptor for the cytotoxic ligand TRAIL

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Evidence that the human death receptor 4 is regulated by activator protein 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Potentiation of the sensitivity of renal cell carcinoma cells to TRAIL-mediated apoptosis by subtoxic concentrations of 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Translating basic cancer research into new cancer therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Cell surface Death Receptor signaling in normal and cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412483200

21 January 2018

Identifiers

10.1074/JBC.M412483200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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