(Q40453947)

20 September 2017

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. (English)

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20 September 2017

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Jodi R Alt

1

1 reference

20 September 2017

Alyssa Bouska

2

1 reference

20 September 2017

Mario R Fernandez

3

1 reference

20 September 2017

Ronald L Cerny

4

1 reference

20 September 2017

Hua Xiao

5

1 reference

20 September 2017

Christine M Eischen

6

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20 September 2017

language of work or name

English

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publication date

25 February 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

19

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20 September 2017

18771-18781

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Direct DNA binding by Brca1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Control of apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Overexpression of the MDM2 oncogene in leukemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The comet assay for DNA damage and repair: principles, applications, and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

DNA damage-dependent nuclear dynamics of the Mre11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Stimulation of human DNA polymerase epsilon by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413387200

21 January 2018

Identifiers

DOI

10.1074/JBC.M413387200

1 reference

20 September 2017

1 reference