(Q40486944)

21 September 2017

title

The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci (English)

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21 September 2017

Wendy W Y Au

1

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21 September 2017

Beric R Henderson

series ordinal

2

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21 September 2017

language of work or name

English

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publication date

29 November 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

280

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21 September 2017

issue

8

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21 September 2017

page(s)

6993-7001

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DNA double-strand breaks: signaling, repair and the cancer connection

21 September 2017

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

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BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

21 January 2018

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

21 January 2018

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

21 January 2018

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The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

21 January 2018

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 January 2018

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

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The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

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Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

21 January 2018

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The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter

21 January 2018

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Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M408879200

Characterization of a carboxy-terminal BRCA1 interacting protein

21 January 2018

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BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

21 January 2018

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Homologous repair of DNA damage and tumorigenesis: the BRCA connection

21 January 2018

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Genetic analysis of BRCA1 function in a defined tumor cell line

21 January 2018

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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

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Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

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53BP1, a mediator of the DNA damage checkpoint

21 January 2018

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

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Genomic instability in mice lacking histone H2AX

21 January 2018

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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

21 January 2018

1 reference

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BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

21 January 2018

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Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.

21 January 2018

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Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

21 January 2018

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Identification of a functional nuclear export sequence in BRCA1.

21 January 2018

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MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

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NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

21 January 2018

1 reference

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 January 2018

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BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

21 January 2018

1 reference

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BRCA1 is associated with the centrosome during mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Control of biochemical reactions through supramolecular RING domain self-assembly

21 January 2018

1 reference

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408879200

21 January 2018

Identifiers

DOI

10.1074/JBC.M408879200

1 reference

21 September 2017

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