(Q40508891)

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Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region

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Europe PubMed Central

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21 September 2017

Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region (English)

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Europe PubMed Central

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21 September 2017

prion protein family

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apoptotic process

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François Major

11

object named as

François Major

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21 September 2017

author name string

Bettina Drisaldi

1

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21 September 2017

Janaky Coomaraswamy

2

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21 September 2017

Peter Mastrangelo

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21 September 2017

Bob Strome

4

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21 September 2017

Jing Yang

5

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21 September 2017

Joel C Watts

6

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21 September 2017

M Azhar Chishti

7

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21 September 2017

Melissa Marvi

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21 September 2017

Otto Windl

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21 September 2017

Rosemary Ahrens

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21 September 2017

Man-Sun Sy

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21 September 2017

Hans Kretzschmar

13

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21 September 2017

Paul E Fraser

14

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21 September 2017

Howard T J Mount

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21 September 2017

David Westaway

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21 September 2017

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publication date

29 September 2004

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21 September 2017

Journal of Biological Chemistry

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21 September 2017

279

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21 September 2017

53

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21 September 2017

55443-55454

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21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

De novo generation of a PrPSc-like conformation in living cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Mammalian prion proteins: enigma, variation and vaccination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Scrapie prion protein contains a phosphatidylinositol glycolipid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

NMR structure of the mouse prion protein domain PrP(121-231)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Two different neurodegenerative diseases caused by proteins with similar structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion protein selectively binds copper(II) ions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

The PrP-like protein Doppel binds copper

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Doppel-induced cerebellar degeneration in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion protein protects human neurons against Bax-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Mammalian prion biology: one century of evolving concepts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Structure and polymorphism of the mouse prion protein gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Grand ideas floating freely. Conference on the new prion biology: basic science, diagnosis and therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Neurotoxicity of a prion protein fragment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prions prevent neuronal cell-line death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Identification of glycoinositol phospholipid linked and truncated forms of the scrapie prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Intercellular transfer of the cellular prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Identification of cryptic nuclear localization signals in the prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Anterograde and retrograde intracellular trafficking of fluorescent cellular prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Metal ions and prion diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Copper stimulates endocytosis of the prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion and doppel proteins bind to granule cells of the cerebellum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Potential pseudoknots in the PrP-encoding mRNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Thermodynamic prediction of conserved secondary structure: application to the RRE element of HIV, the tRNA-like element of CMV and the mRNA of prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

RNA molecules stimulate prion protein conversion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

NMR structure of the human doppel protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Prion protein is necessary for normal synaptic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

Altered circadian activity rhythms and sleep in mice devoid of prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404794200

21 January 2018

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10.1074/JBC.M404794200

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Europe PubMed Central

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21 September 2017

release_yicuz4mmxbcizo25yywlkhi5yu

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https://api.fatcat.wiki/v0/release/yicuz4mmxbcizo25yywlkhi5yu

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Europe PubMed Central

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21 September 2017

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