(Q40517893)

21 September 2017

title

Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin (English)

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ubiquitin-proteasome system

21 September 2017

main subject

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Jongkyu Choi

1

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21 September 2017

Sun Young Park

2

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21 September 2017

Frank Costantini

3

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21 September 2017

Eek-Hoon Jho

4

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21 September 2017

Choun-Ki Joo

5

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21 September 2017

language of work or name

English

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publication date

7 September 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

47

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21 September 2017

page(s)

49188-49198

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Linking colorectal cancer to Wnt signaling

21 September 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

21 January 2018

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21 January 2018

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Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

21 January 2018

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Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

21 January 2018

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21 January 2018

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Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

21 January 2018

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

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21 January 2018

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21 January 2018

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Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

21 January 2018

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Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

21 January 2018

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

21 January 2018

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

21 January 2018

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beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

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Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway

21 January 2018

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

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Dimer formation by an N-terminal coiled coil in the APC protein

21 January 2018

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21 January 2018

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The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin

21 January 2018

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Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

21 January 2018

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 January 2018

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Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon

21 January 2018

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Structural basis of the Axin-adenomatous polyposis coli interaction

21 January 2018

1 reference

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Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

21 January 2018

1 reference

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

1 reference

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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

21 January 2018

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Functional domains of axin. Importance of the C terminus as an oligomerization domain

21 January 2018

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The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

21 January 2018

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21 January 2018

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The subcellular destinations of APC proteins

21 January 2018

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Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein

21 January 2018

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Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

21 January 2018

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Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

21 January 2018

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Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis

21 January 2018

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Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation

21 January 2018

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Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

21 January 2018

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Identification of deletion mutations and three new genes at the familial polyposis locus

21 January 2018

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APC gene: database of germline and somatic mutations in human tumors and cell lines

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M404655200

1 reference

21 September 2017

1 reference