(Q40524598)

21 September 2017

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport (English)

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21 September 2017

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2

Thomas C Südhof

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21 September 2017

Mikhail Khvotchev

1

1 reference

PubMed ID

15316009

21 September 2017

language of work or name

English

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publication date

16 August 2004

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Journal of Biological Chemistry

21 September 2017

8

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published in

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21 September 2017

279

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21 September 2017

47101-47108

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21 September 2017

45

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It all sticks together--the APP-related family of proteins and Alzheimer's disease

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

The presenilins in Alzheimer's disease--proteolysis holds the key.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Implication of APP secretases in notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Complexins: cytosolic proteins that regulate SNAP receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Essential functions of synapsins I and II in synaptic vesicle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

SNARE-mediated membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Constitutive and regulated secretion of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Characterization of a cis-Golgi matrix protein, GM130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Role of endoplasmic reticulum, endosomal-lysosomal compartments, and microtubules in amyloid precursor protein metabolism of human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

GAL4-VP16 is an unusually potent transcriptional activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408474200

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

21 January 2018

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M408474200

Identifiers

DOI

10.1074/JBC.M408474200

1 reference

21 September 2017

1 reference

PubMed ID

15316009