(Q40546166)

English

Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway

scientific article published on July 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

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author name string

Debiais F

1

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21 September 2017

Lefèvre G

2

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21 September 2017

Lemonnier J

3

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21 September 2017

Le Mée S

4

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21 September 2017

Lasmoles F

5

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21 September 2017

Mascarelli F

6

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21 September 2017

Marie PJ

7

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21 September 2017

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publication date

1 July 2004

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21 September 2017

Experimental Cell Research

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21 September 2017

297

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21 September 2017

1

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21 September 2017

235-246

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21 September 2017

Transcriptional control of osteoblast growth and differentiation

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Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1

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Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines

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Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts

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Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.

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Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway

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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

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Fibroblast growth factor signaling controlling osteoblast differentiation

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The effects of fibroblast growth factor-2 on human neonatal calvaria osteoblastic cells are differentiation stage specific

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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

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The Ser252Trp fibroblast growth factor receptor-2 (FGFR-2) mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation

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Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts

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Stimulation of sodium-dependent phosphate transport and signaling mechanisms induced by basic fibroblast growth factor in MC3T3-E1 osteoblast-like cells.

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Basic fibroblast growth factor stimulates vascular endothelial growth factor release in osteoblasts: divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase

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The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells

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Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts

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Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.

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The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2

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Acidic fibroblast growth factor signaling inhibits peroxynitrite-induced death of osteoblasts and osteoblast precursors

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p110δ, a novel phosphoinositide 3-kinase in leukocytes

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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Missing links in GSK3 regulation.

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Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

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Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells

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beta-catenin is a target for the ubiquitin-proteasome pathway

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Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction

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Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter

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Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

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Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

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Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells.

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

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Endogenous FGF1-induced activation and synthesis of extracellular signal-regulated kinase 2 reduce cell apoptosis in retinal-pigmented epithelial cells

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Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

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Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.

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Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells

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Biochemical pathways of caspase activation during apoptosis

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Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.

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Mechanism of activation and function of protein kinase B.

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

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Identifiers

10.1016/J.YEXCR.2004.03.032

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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