(Q40549606)

21 September 2017

title

A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. (English)

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21 September 2017

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Margaret N Kennedy

1

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21 September 2017

Gregory E D Mullen

2

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21 September 2017

Cynthia A Leifer

3

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21 September 2017

ChangWoo Lee

4

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21 September 2017

Alessandra Mazzoni

5

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21 September 2017

Kottarappat N Dileepan

6

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21 September 2017

David M Segal

7

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21 September 2017

language of work or name

English

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publication date

1 June 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

33

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21 September 2017

page(s)

34698-34704

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Innate immune sensing and its roots: the story of endotoxin

21 September 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M405444200

Bacterial lipopolysaccharides and innate immunity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405444200

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

MD-2, a novel accessory molecule, is involved in species-specific actions of Salmonella lipid A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

The immune response of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

Leucine-rich repeats and pathogen recognition in Toll-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

TLR signaling at the intestinal epithelial interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405444200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405444200

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21 September 2017

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