(Q40559827)

21 September 2017

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus (English)

1 reference

21 September 2017

1 reference

Matthew E Hartman

1

1 reference

21 September 2017

Jason C O'Connor

2

1 reference

21 September 2017

Jonathan P Godbout

3

1 reference

21 September 2017

Kyle D Minor

4

1 reference

21 September 2017

Valerie R Mazzocco

5

1 reference

21 September 2017

Gregory G Freund

6

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21 September 2017

language of work or name

English

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publication date

27 April 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

27

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21 September 2017

28045-28050

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Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The IRS-signalling system during insulin and cytokine action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Insulin receptor substrate proteins and neuroendocrine function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The IL-4 receptor: signaling mechanisms and biologic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The many faces of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Cell biology of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Upregulation of macrophage lipoprotein lipase in patients with type 2 diabetes: role of peripheral factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Identification of enhanced serine kinase activity in insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Rapamycins: mechanism of action and cellular resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in Type 2 diabetics and patients with android type obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Tumour necrosis factor alpha: a key regulator of adipose tissue mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404368200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404368200

1 reference

21 September 2017

1 reference