(Q40566850)

21 September 2017

title

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation (English)

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21 September 2017

5

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21 September 2017

4

Ya-Min Tian

1 reference

21 September 2017

Yukio Kageyama

1

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21 September 2017

Minori Koshiji

series ordinal

2

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21 September 2017

Kenneth K W To

series ordinal

3

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21 September 2017

L Eric Huang

series ordinal

6

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21 September 2017

language of work or name

English

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publication date

14 April 2004

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21 September 2017

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21 September 2017

volume

18

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21 September 2017

issue

9

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21 September 2017

page(s)

1028-1030

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 September 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Hypoxia-inducible factor and its biomedical relevance

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Oxygen sensing and molecular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1096/FJ.03-1233FJE

Identifiers

DOI

10.1096/FJ.03-1233FJE

1 reference

21 September 2017

1 reference