(Q40573761)

21 September 2017

Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response (English)

1 reference

21 September 2017

Gerald A Higgins

1

1 reference

PubMed ID

26340055

21 September 2017

Ari Allyn-Feuer

series ordinal

2

1 reference

PubMed ID

26340055

21 September 2017

Brian D Athey

series ordinal

3

1 reference

21 September 2017

4 September 2015

1 reference

21 September 2017

1 reference

21 September 2017

16

1 reference

21 September 2017

14

1 reference

21 September 2017

1565-1583

1 reference

Insights from genome-wide association studies of drug response

21 September 2017

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

21 January 2018

Omics and drug response

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A role for noncoding variation in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetic and epigenetic fine mapping of causal autoimmune disease variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Functional annotation of colon cancer risk SNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide analysis of noncoding regulatory mutations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A molecular basis for classic blond hair color in Europeans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genomewide association studies and assessment of the risk of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Systematic localization of common disease-associated variation in regulatory DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetic architectures of psychiatric disorders: the emerging picture and its implications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Defining functional DNA elements in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Topological domains in mammalian genomes identified by analysis of chromatin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

CTCF and cohesin: linking gene regulatory elements with their targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

An integrated encyclopedia of DNA elements in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Integrative analysis of 111 reference human epigenomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Nuclease hypersensitive sites in chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Annotation of functional variation in personal genomes using RegulomeDB

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Integrative analysis of haplotype-resolved epigenomes across human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Revitalizing psychiatric therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The 3DGD: a database of genome 3D structure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Prioritizing candidate disease genes by network-based boosting of genome-wide association data.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The Human Epigenome Browser at Washington University

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

ENCODE whole-genome data in the UCSC Genome Browser

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The UCSC Genome Browser database: 2014 update

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Recent developments in genome and exome-wide analyses of plasma lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genenames.org: the HGNC resources in 2013

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

dbSNP: the NCBI database of genetic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The Genotype-Tissue Expression (GTEx) project

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

ChromHMM: automating chromatin-state discovery and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A circadian gene expression atlas in mammals: implications for biology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Discovery and refinement of loci associated with lipid levels

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Association of OPRD1 polymorphisms with heroin dependence in a large case-control series

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association study of a quantitative disordered gambling trait

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Bio-informatics based analysis of genes implicated in alcohol mediated liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Contactins in the neurobiology of autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Molecular basis for prospective pharmacological treatment strategies in intellectual disability syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

The genetics of neurodevelopmental disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Influence of an interaction between lithium salts and a functional polymorphism in SLC1A2 on the history of illness in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genome-wide association study of antipsychotic-induced QTc interval prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

NQO2 gene is associated with clozapine-induced agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

NQO2 is a reactive oxygen species generating off-target for acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Unsupervised pattern discovery in human chromatin structure through genomic segmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Linking disease associations with regulatory information in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

An anatomically comprehensive atlas of the adult human brain transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Spatio-temporal transcriptome of the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Biased allelic expression in human primary fibroblast single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Active genes dynamically colocalize to shared sites of ongoing transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Allele-specific gene expression is widespread across the genome and biological processes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Allelic skewing of DNA methylation is widespread across the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Heritable individual-specific and allele-specific chromatin signatures in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A brief history of opiates, opioid peptides, and opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Beyond GWASs: illuminating the dark road from association to function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.105

21 January 2018

Identifiers

DOI

10.2217/PGS.15.105

1 reference

21 September 2017

1 reference

PubMed ID

26340055